"The dynamic transcriptional and epigenetic landscape of human ILCs"

Jenny Mjösberg

Associate Professor at the Center for Infectious Medicine (CIM), Karolinska Institutet, Stockholm, Sweden

Jenny Mjösberg is an associate professor at the Center for Infectious Medicine (CIM), Karolinska Institutet, Stockholm, Sweden. She earned her PhD in reproductive immunology at Linköping University, Sweden, in 2010. During her postdoc period in the lab of Hergen Spits at the AMC, Amsterdam, she contributed to the discovery of two novel subsets of human ILCs; ILC2 and ILC1. Since 2013, research in her own lab at CIM is focused on the importance of human ILCs in mucosal homeostasis and inflammation, mainly in the lung and gastrointestinal tract. Importantly, in 2016 Mjösberg provided the first transcriptional characterization of human ILCs on the single-cell level. These studies, along with continued transcriptional and epigenetic dissection of ILCs across several human organs have revealed previously unknown heterogeneity and a plethora of characteristics and regulatory mechanisms that control the function of specific ILC subsets. Her group ultimately aims at understanding the role of ILCs in asthma and gastrointestinal disease, including colorectal cancer and inflammatory bowel disease, for the development of novel therapeutic concepts.